Rat Atrial Natriuretic Peptide (ANP) Protein

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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ANP
proveedor
Abbexareference
abx065486Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Atrial Natriuretic Peptide (ANP) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Atrial Natriuretic Peptide (ANP) is a hormone secreted primarily by cardiac atrial myocytes in response to increased blood volume or pressure, playing a pivotal role in cardiovascular and fluid homeostasis. ANP exerts its effects by binding to natriuretic peptide receptor-A (NPR-A), leading to increased intracellular cyclic guanosine monophosphate (cGMP) levels, which mediate vasodilation and natriuresis. This hormone reduces systemic vascular resistance and promotes sodium and water excretion in the kidneys, thereby lowering blood pressure and blood volume. ANP is also a critical regulator of the renin-angiotensin-aldosterone system (RAAS), counteracting the effects of angiotensin II and aldosterone to prevent fluid overload. Clinically, elevated ANP levels are observed in conditions like heart failure and atrial fibrillation, serving as a biomarker for these diseases. Therapeutically, recombinant ANP and analogs are being explored for their potential in treating acute decompensated heart failure and hypertension. Research also highlights ANP’s role in protecting against cardiac hypertrophy, fibrosis, and remodeling, emphasizing its broader significance in cardiovascular health and disease management.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Atrial Natriuretic Peptide (ANP)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 12.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn25-Arg122 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ANP
dry ice
No
availability
Shipped within 5-12 working days.
alias
NPPA,ANF,ANP,ATFB6,Atrial natriuretic factor
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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