Rat Apolipoprotein C-I (APOC1) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein APOC1
proveedor
Abbexareference
abx065419Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Apolipoprotein C-I (APOC1) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
APOC1 is a small protein mainly associated with high-density lipoproteins (HDL), and to a lesser extent with very-low-density lipoproteins (VLDL) and chylomicrons. It is synthesized primarily in the liver and plays a crucial role in lipid metabolism by modulating the activity of lipoprotein lipase (LPL) and cholesteryl ester transfer protein (CETP). APOC1 inhibits CETP, thereby reducing the transfer of cholesteryl esters from HDL to LDL and VLDL, which promotes HDL cholesterol levels. It also regulates triglyceride metabolism by modulating lipolytic activity, thereby influencing plasma lipid homeostasis. Elevated APOC1 levels have been associated with dyslipidemia, atherosclerosis, and an increased risk of cardiovascular diseases. It may also play a role in inflammatory responses and has been linked to neurodegenerative diseases like Alzheimer’s disease, where it interacts with amyloid-beta peptides. Research indicates APOC1 has a protective role in the reverse cholesterol transport pathway, facilitating cholesterol efflux from peripheral tissues back to the liver. Genetic variations in the APOC1 gene influence plasma lipid profiles and susceptibility to metabolic disorders, including obesity and insulin resistance.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Apolipoprotein C-I (APOC1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 38.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met34-Ala88 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
APOC1
dry ice
No
availability
Shipped within 5-7 working days.
alias
APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1, Apolipoprotein C-I
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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