Rat Antithrombin-III (SERPINC1) Protein

Product specifications

Proteins and Peptides

HEK293 cells

Rat

Molecular Weight: Calculated MW: 51.04 kDa  Observed MW (SDS-PAGE): 60 kDa
Sequence Fragment: Met1-Asn465
Tag: C-terminal His tag

Recombinant

>95% (SDS-PAGE)

20 µg

100 µg

Lyophilized Reconstitute in sterile H2O. Do not vortex.

SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.

Shipped within 5-15 working days.

Store lyophilized between -20 °C and -80 °C.

No

Q5M7T5

AT3,AT3D,ATIII,THPH7,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin-III,Serpin C1

Protein SERPINC1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

SERPINC1, commonly known as the gene encoding antithrombin (AT), is a critical member of the serine protease inhibitor (serpin) family. Antithrombin is primarily synthesized in the liver and secreted into the bloodstream, where it plays a vital role in regulating blood coagulation. As a serpin, its primary function is to inhibit proteases involved in coagulation, such as thrombin and factor Xa, thereby preventing excessive clot formation. Deficiencies or abnormalities in the SERPINC1 gene are closely associated with thrombotic disorders, as they lead to an increased risk of blood clots due to insufficient antithrombin activity. This deficiency can be inherited or acquired, and it plays a significant role in conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE).

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