Rat Ankyrin Repeat Domain Protein 1 (ANKRD1) Protein

Este producto es parte de ANKRD - Ankyrin repeat domain
Rat Ankyrin Repeat Domain Protein 1 (ANKRD1) Protein
234€ (10 µg)

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Name
Rat Ankyrin Repeat Domain Protein 1 (ANKRD1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650699
Tested Applications
WB, SDS-PAGE

Description

Rat ANKRD1 Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
Ankyrin Repeat Domain Protein 1 (ANKRD1)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Arg5-Asn279
Tag: N-terminal His tag and GST tag
Origin
Rat
Conjugation
Unconjugated
Observed MW
Calculated MW: 61.1 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
Q8R560
Alias
ALRP,C-193,CARP,CVARP
Background
Protein ANKRD1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

ANKRD1, also known as Cardiac Ankyrin Repeat Protein (CARP), is a transcriptional regulator predominantly expressed in cardiac and skeletal muscles. It localizes to the nucleus and sarcomere, where it interacts with structural proteins like titin and myopalladin. ANKRD1 functions as a stress response protein, upregulated during mechanical stress, injury, and pathological remodeling of the heart. It regulates gene expression through its interaction with transcription factors and participates in processes such as cardiomyocyte differentiation, sarcomeric assembly, and cellular mechanosensing. Mutations or dysregulation of ANKRD1 are associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), where it contributes to altered heart function and structure. ANKRD1 also plays a role in fibrosis, angiogenesis, and cellular signaling pathways activated during heart failure and stress adaptation, making it a potential biomarker for cardiac disorders.

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