Rat Ankyrin Repeat Domain Protein 1 (ANKRD1) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ANKRD1
proveedor
Abbexareference
abx650699Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat ANKRD1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
ANKRD1, also known as Cardiac Ankyrin Repeat Protein (CARP), is a transcriptional regulator predominantly expressed in cardiac and skeletal muscles. It localizes to the nucleus and sarcomere, where it interacts with structural proteins like titin and myopalladin. ANKRD1 functions as a stress response protein, upregulated during mechanical stress, injury, and pathological remodeling of the heart. It regulates gene expression through its interaction with transcription factors and participates in processes such as cardiomyocyte differentiation, sarcomeric assembly, and cellular mechanosensing. Mutations or dysregulation of ANKRD1 are associated with dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), where it contributes to altered heart function and structure. ANKRD1 also plays a role in fibrosis, angiogenesis, and cellular signaling pathways activated during heart failure and stress adaptation, making it a potential biomarker for cardiac disorders.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Ankyrin Repeat Domain Protein 1 (ANKRD1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 61.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg5-Asn279 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ANKRD1
dry ice
No
availability
Shipped within 5-7 working days.
alias
ALRP,C-193,CARP,CVARP
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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