Rat Angiotensinogen (AGT) Protein

Este producto es parte de AGT - Angiotensinogen
Rat Angiotensinogen (AGT) Protein

Pida mas información

935106861

info@markelab.com

Precio

403€ (50 µg)

Protein AGT

proveedor

Abbexa

reference

abx651468

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Angiotensinogen (AGT) Protein is a Rat protein produced in 293F cell.


Background

Angiotensinogen (AGT) is a protein primarily produced and secreted by the liver, although it is also synthesized by other tissues, including the kidney and adipose tissue. It serves as the precursor molecule for the renin-angiotensin system (RAS), a key regulatory pathway involved in blood pressure regulation, fluid balance, and electrolyte homeostasis. AGT is converted into angiotensin I by the enzyme renin, which is released by the kidneys in response to various stimuli, such as decreased blood pressure or sodium levels. Angiotensin I is further converted into angiotensin II by angiotensin-converting enzyme (ACE), leading to vasoconstriction, aldosterone release, and sodium reabsorption, ultimately raising blood pressure. Dysregulation of the RAS, including alterations in AGT levels, has been implicated in hypertension, cardiovascular disease, and kidney disorders. Therapeutic interventions targeting the RAS, such as ACE inhibitors and angiotensin receptor blockers, are commonly used to manage hypertension and related conditions. Understanding the role of AGT in the RAS provides insights into cardiovascular health and potential avenues for therapeutic intervention. Ongoing research continues to elucidate the intricate mechanisms underlying AGT regulation and its implications for human health and disease

Características del producto

category

Proteins and Peptides


origin

Rat


host

293F cell


immunogen target

Angiotensinogen (AGT)


host

293F cell


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 51.2 kDa Observed MW: 60 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp25-Val477 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

AGT


dry ice

No


availability

Shipped within 5-7 working days.


alias

ANHU,SERPINA8,hFLT1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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