Rat Angiotensin II Receptor 2 (AGTR2) Protein
1872€ (1 mg)
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name
Rat Angiotensin II Receptor 2 (AGTR2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652522
tested applications
WB, SDS-PAGE
Description
Rat Angiotensin II Receptor 2 (AGTR2) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Angiotensin II Receptor 2 (AGTR2) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AGTR2,AT2, ATGR2, MRX88,angiotensin receptor 2,angiotensin II type 2 receptor,AT2 receptor,Agtr2 |
| Background | Protein AGTR2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
AGTR2 is a G-protein-coupled receptor (GPCR) that binds angiotensin II, exerting effects that often counterbalance the actions of the angiotensin II receptor type 1 (AGTR1). AGTR2 is expressed in various tissues, including the fetal nervous system, vascular endothelium, kidneys, and heart, and its expression decreases after birth but remains significant in specific contexts, such as injury or disease. Unlike AGTR1, AGTR2 primarily mediates vasodilation, anti-inflammatory effects, antiproliferative actions, and pro-apoptotic signaling, contributing to cardiovascular and tissue protection. AGTR2 signaling involves activation of protein phosphatases, nitric oxide (NO) production, and the modulation of signaling pathways like p38 MAPK and Akt, promoting its protective effects on the vasculature and reducing oxidative stress. Dysregulation of AGTR2 has been linked to vascular remodeling, hypertension, and neurological disorders, including cerebral ischemia and neurodegeneration. Additionally, AGTR2 is implicated in promoting angiogenesis and maintaining neuronal growth during development.
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