Rat Angiotensin I Converting Enzyme 2 (ACE2) Protein
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935106861
info@markelab.com
Precio
247€ (10 µg)
Protein ACE2
proveedor
Abbexareference
abx167751Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Angiotensin I Converting Enzyme 2 Protein is a recombinant Rat protein expressed in E. coli.
Background
Angiotensin I Converting Enzyme 2 (ACE2) is a transmembrane protein that serves as a key regulator of the renin-angiotensin system (RAS) by catalyzing the conversion of angiotensin II (a potent vasoconstrictor) into angiotensin 1-7, which has vasodilatory, anti-inflammatory, and anti-fibrotic effects. ACE2 is highly expressed in the lungs, heart, kidneys, and gastrointestinal tract, and it plays a crucial role in maintaining cardiovascular and pulmonary homeostasis. Beyond its enzymatic function, ACE2 gained significant attention as the cellular entry receptor for the SARS-CoV and SARS-CoV-2 viruses, where it facilitates viral binding and internalization via interactions with the viral spike (S) protein. Dysregulation of ACE2 expression has been implicated in conditions such as hypertension, heart failure, acute lung injury, and COVID-19-related complications. Therapeutic strategies targeting ACE2, such as recombinant soluble ACE2 and RAS modulators, are being explored to counteract these pathologies. ACE2's dual role in regulating vascular function and serving as a viral receptor highlights its significance in both physiology and disease.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Angiotensin I Converting Enzyme 2 (ACE2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 43.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu392-Val739 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ACE2
dry ice
No
availability
Shipped within 5-7 working days.
alias
ACEH,Peptidyl-Dipeptidase A
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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