Rat Angiopoietin 4 (ANGPT4) Protein

Product specifications

Proteins and Peptides

Angiopoietin 4 (ANGPT4)

E. coli

Rat

Unconjugated

Molecular Weight: Calculated MW: 28.7 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Arg272-Phe489
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

ANG3,ANG4

Protein ANGPT4

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ANGPT4 is a member of the angiopoietin family of secreted glycoproteins that regulate angiogenesis and vascular remodeling through interactions with the Tie2 receptor on endothelial cells. ANGPT4 shares structural and functional similarities with ANGPT1 but has distinct tissue-specific expression patterns. It promotes endothelial cell survival and vascular stabilization in certain contexts, although its precise role can vary depending on the tissue and physiological conditions. ANGPT4 is expressed in the lung and other vascularized tissues, where it contributes to blood vessel formation and repair during development and tissue regeneration. Unlike ANGPT2, which promotes vascular destabilization, ANGPT4 generally supports vascular integrity, but its role as an agonist or antagonist of Tie2 signaling can depend on the cellular microenvironment. Dysregulation of ANGPT4 has been implicated in tumor angiogenesis and vascular diseases, where it may enhance abnormal vessel growth and contribute to cancer progression. Its role in vascular biology highlights ANGPT4 as a potential therapeutic target for modulating angiogenesis in disease contexts.

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