Rat Amyloid Beta 40 (Abeta40) ELISA Kit
proveedor
Abbexareference
abx053396Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Amyloid Beta 40 (Abeta40) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Amyloid Beta 40 (Abeta40) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Background
Amyloid beta (Aβ or Abeta) is a term used to describe peptides composed of 36 to 43 amino acids, and they constitute the primary component of the amyloid plaques found within the brains of individuals suffering from Alzheimer's disease. These peptides are derived from the amyloid-beta precursor protein (APP).The formation of β-amyloid occurs through the sequential cleavage of a transmembrane protein known as APP, which is a glycoprotein serving as its precursor. Among the various forms, the most extensively studied variants are Aβ42 and Aβ40 (Abeta40 and Abeta42). The sole distinction between Aβ42 and Aβ40 is the presence of two additional residues at the C-terminus of Aβ42.The generation of Aβ from its precursor protein, APP, is orchestrated by enzymes known as gamma- and β-secretases. Aβ can be found circulating in plasma, cerebrospinal fluid (CSF), and brain interstitial fluid (ISF), predominantly in the soluble Aβ40 form. Notably, amyloid plaques contain both Aβ40 and Aβ42.The amyloid-beta peptide is believed to play a central role in the pathology of Alzheimer's disease. Sporadic Alzheimer's disease is the most prevalent cause of dementia, contributing to an estimated 50% to 56% of cases in autopsy and clinical series.Furthermore, Aβ production appears to have a close relationship with the Aβ precursor protein, APP, and mitochondria, which serve as the primary energy source for the brain. Microglial cells also play crucial roles in removing accumulated Aβ, not only through phagocytosis but also by releasing proteases for degradation. Terms related :Tau protein, Fosfo Tau,nptx2, STREM2
Background
Beta amiloide (Aβ o Abeta) es un término utilizado para describir péptidos compuestos de 36 a 43 aminoácidos y constituyen el componente principal de las placas amiloides que se encuentran en el cerebro de personas que padecen la enfermedad de Alzheimer. Estos péptidos se derivan de la proteína precursora del beta-amiloide (APP). La formación del β-amiloide se produce mediante la escisión secuencial de una proteína transmembrana conocida como APP, que es una glicoproteína que actúa como su precursora. Entre las diversas formas, las variantes más estudiadas son Aβ42 y Aβ40 (Abeta40 y Abeta42). La única distinción entre Aβ42 y Aβ40 es la presencia de dos residuos adicionales en el extremo C de Aβ42. La generación de Aβ a partir de su proteína precursora, APP, está orquestada por enzimas conocidas como gamma y β-secretasas. El Aβ se puede encontrar circulando en plasma, líquido cefalorraquídeo (LCR) y líquido intersticial cerebral (ISF), predominantemente en la forma Aβ40 soluble. En particular, las placas amiloides contienen tanto Aβ40 como Aβ42. Se cree que el péptido beta-amiloide desempeña un papel central en la patología de la enfermedad de Alzheimer. La enfermedad de Alzheimer esporádica es la causa más frecuente de demencia y contribuye aproximadamente entre el 50% y el 56% de los casos en autopsias y series clínicas. Además, la producción de Aβ parece tener una estrecha relación con la proteína precursora de Aβ, la APP y las mitocondrias, que Sirven como fuente primaria de energía para el cerebro. Las células microgliales también desempeñan un papel crucial en la eliminación del Aβ acumulado, no sólo mediante la fagocitosis sino también mediante la liberación de proteasas para su degradación. Términos relacionados: proteína Tau, Fosfo Tau, nptx2, STREM2
Características del producto
category
ELISA Kits
immunogen target
Amyloid Beta 40 (Abeta40)
reactivity
Rat
test range
2.47 pg/ml - 200 pg/ml
sensitivity
< 1.18 pg/ml
assay type
Competitive
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
Aβ40|Amyloid Beta 40|Abeta 40|Beta-amyloid protein 40|Aβ|1-40
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
Abeta40
dry ice
No
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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