Rat Aminolevulinate Delta Synthase 1 (ALAS1) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rat Aminolevulinate Delta Synthase 1 (ALAS1) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Aminolevulinate Delta Synthase 1 (ALAS1) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 62 kDa Observed MW (SDS-PAGE): 62 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys355-Ala642 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ALAS1,ALAS3,ALASH,Delta-ALA synthase 1 |
| Background | Protein ALAS1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
5-Aminolevulinate Synthase 1 (ALAS1) is the ubiquitously expressed, non-specific isoform of the enzyme catalyzing the first and rate-limiting step of heme biosynthesis. ALAS1 converts glycine and succinyl-CoA into 5-aminolevulinic acid (ALA) within mitochondria, a critical precursor in the heme production pathway. Its expression and activity are tightly regulated by intracellular heme levels, reflecting its central role in maintaining heme homeostasis. ALAS1 is induced in response to increased demand for cytochromes in liver cells, particularly during drug metabolism and detoxification processes mediated by cytochrome P450 enzymes. Dysregulation of ALAS1 can lead to disorders such as acute intermittent porphyria (AIP), characterized by the accumulation of toxic heme precursors, resulting in neurovisceral symptoms. Therapeutic modulation of ALAS1 activity, including heme supplementation or small-molecule inhibitors, is a key strategy in managing porphyric crises and related metabolic dysfunctions.
Related Products
Recombinant Human ALAS1
Ver Producto
Aminolevulinate Delta Synthase 1 (ALAS1) Antibody
ALAS1 Antibody is a Rabbit Polyclonal antibody against ALAS1. This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Ver Producto
Rat Aminolevulinate delta Synthase 1 (ALAS1) ELISA Kit
Rat Aminolevulinate delta Synthase 1 (ALAS1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Aminolevulinate delta Synthase 1 (ALAS1) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Aminolevulinate Delta Synthase 1 (ALAS1)
Ver Producto