Rat Aminoacylase-1A (ACY1) ELISA Kit
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Description
Rat Aminoacylase-1A (ACY1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Aminoacylase-1A concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aminoacylase-1A (ACY1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.78 ng/ml - 50 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6AYS7 |
| Alias | N-acyl-L-amino-acid amidohydrolase,ACY-1 |
| Background | Elisa kits for ACY1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACY1 is a cytosolic enzyme responsible for catalyzing the hydrolysis of N-acylated amino acids into free amino acids and their corresponding acyl groups. This process is crucial for the metabolism and recycling of amino acids, particularly in tissues like the liver and kidneys, where ACY1 contributes to nitrogen balance and detoxification. ACY1 plays a role in regulating the intracellular pool of amino acids for protein synthesis and metabolic processes. Deficiency in ACY1 activity, caused by genetic mutations, leads to aminoacylase 1 deficiency, a rare metabolic disorder characterized by the accumulation of N-acetylated amino acids in the urine, with possible neurological and developmental consequences. In addition to its metabolic role, ACY1 is expressed in certain cancers, where it may influence tumor metabolism and growth. Its enzymatic function in amino acid metabolism underscores its importance in cellular and systemic homeostasis.
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Human ACY1(aminoacylase-1) ELISA Kit
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Aminoacylase 1 (ACY1) Antibody
ACY1 Antibody is a Rabbit Polyclonal antibody against ACY1. This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18.
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