Rat Aldehyde Dehydrogenase X, Mitochondrial (ALDH1B1) ELISA Kit

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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715€ (96 tests)

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935106861
info@markelab.com
name
Rat Aldehyde Dehydrogenase X, Mitochondrial (ALDH1B1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501469
tested applications
ELISA

Description

Rat Aldehyde Dehydrogenase X, Mitochondrial (ALDH1B1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Aldehyde dehydrogenase X, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryELISA Kits
Immunogen TargetAldehyde Dehydrogenase X, Mitochondrial (ALDH1B1)
ReactivityRat
Detection MethodColorimetric
Assay DataQuantitative
Test Range0.156 ng/ml - 10 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
FormLyophilized
Tested ApplicationsELISA
Sample TypeTissue homogenates, cell lysates and other biological fluids.
AvailabilityShipped within 5-15 working days. The validity for this kit is 6 months.
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
UniProt IDQ66HF8
AliasALDH1B1,ALDH5,ALDHX
BackgroundElisa kits for ALDH1B1
StatusRUO
NoteValidity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALDH1B1 is a mitochondrial enzyme that participates in the detoxification of aldehydes and the oxidation of acetaldehyde to acetate, a key step in ethanol metabolism. It is highly expressed in the liver, colon, and gastrointestinal tract, where it protects against oxidative stress and aldehyde-induced cellular damage. ALDH1B1 has been linked to alcohol metabolism, and its dysregulation contributes to alcohol-induced liver injury, cirrhosis, and colorectal cancer. In cancers, ALDH1B1 expression is often elevated, particularly in colorectal and pancreatic tumors, where it promotes tumorigenesis by maintaining cellular redox balance and enhancing proliferation. It also contributes to cancer stem-like properties, facilitating chemoresistance and tumor progression. Studies suggest ALDH1B1 as a promising biomarker and therapeutic target in gastrointestinal cancers and alcohol-associated diseases. Its role in mitochondrial aldehyde metabolism also links it to energy homeostasis and metabolic regulation.

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