Rat Aldehyde Dehydrogenase, Mitochondrial (ALDH2) CLIA Kit
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Description
Rat ALDH2 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.
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Product specifications
| Category | CLIA Kits |
| Immunogen Target | Aldehyde Dehydrogenase, Mitochondrial (ALDH2) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.781 ng/ml - 50 ng/ml |
| Sensitivity | < 0.33 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ALDH2,ALDM,ALDH class 2 |
| Background | CLIA Kits ALDH2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALDH2 is a mitochondrial enzyme primarily responsible for the oxidation of acetaldehyde, a toxic intermediate produced during ethanol metabolism, into acetate. It plays a key role in alcohol detoxification, protecting cells from acetaldehyde-induced toxicity, which can lead to DNA damage, lipid peroxidation, and oxidative stress. ALDH2 also detoxifies reactive aldehydes generated during lipid peroxidation, such as 4-hydroxynonenal (4-HNE), and participates in mitochondrial redox balance. A common mutation in the ALDH2 gene, known as ALDH2*2, reduces enzymatic activity and is prevalent in East Asian populations, leading to alcohol intolerance, increased cancer risk (e.g., esophageal cancer), and cardiovascular diseases. ALDH2 is also protective against ischemic heart injury, as it reduces oxidative damage during cardiac stress. Its role in aldehyde detoxification and mitochondrial function highlights ALDH2 as a therapeutic target for alcohol-related diseases, cancer prevention, and cardiovascular disorders.
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anti- ALDH2 antibody
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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