Rat Aldehyde Dehydrogenase, Mitochondrial (ALDH2) CLIA Kit

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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845€ (96 tests)

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935106861
info@markelab.com
name
Rat Aldehyde Dehydrogenase, Mitochondrial (ALDH2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx493389
tested applications
CLIA

Description

Rat ALDH2 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryCLIA Kits
Immunogen TargetAldehyde Dehydrogenase, Mitochondrial (ALDH2)
ReactivityRat
Detection MethodChemiluminescent
Assay DataQuantitative
Assay TypeSandwich
Test Range0.781 ng/ml - 50 ng/ml
Sensitivity< 0.33 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
Size 25 × 96 tests
Size 310 × 96 tests
FormLyophilized
Tested ApplicationsCLIA
Sample TypeSerum, plasma, tissue homogenates and other biological fluids.
AvailabilityShipped within 5-20 working days.
Storage Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
AliasALDH2,ALDM,ALDH class 2
BackgroundCLIA Kits ALDH2
StatusRUO
NoteThe validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ALDH2 is a mitochondrial enzyme primarily responsible for the oxidation of acetaldehyde, a toxic intermediate produced during ethanol metabolism, into acetate. It plays a key role in alcohol detoxification, protecting cells from acetaldehyde-induced toxicity, which can lead to DNA damage, lipid peroxidation, and oxidative stress. ALDH2 also detoxifies reactive aldehydes generated during lipid peroxidation, such as 4-hydroxynonenal (4-HNE), and participates in mitochondrial redox balance. A common mutation in the ALDH2 gene, known as ALDH2*2, reduces enzymatic activity and is prevalent in East Asian populations, leading to alcohol intolerance, increased cancer risk (e.g., esophageal cancer), and cardiovascular diseases. ALDH2 is also protective against ischemic heart injury, as it reduces oxidative damage during cardiac stress. Its role in aldehyde detoxification and mitochondrial function highlights ALDH2 as a therapeutic target for alcohol-related diseases, cancer prevention, and cardiovascular disorders.

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