Rat Aldehyde Dehydrogenase 7 Family Member A1 (ALDH7A1) ELISA Kit

Este producto es parte de ALDH - Aldehyde dehydrogenase family member
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715€ (96 tests)

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935106861
info@markelab.com
name
Rat Aldehyde Dehydrogenase 7 Family Member A1 (ALDH7A1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx501507
tested applications
ELISA

Description

Rat Aldehyde Dehydrogenase 7 Family Member A1 (ALDH7A1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Alpha-aminoadipic semialdehyde dehydrogenase concentrations in tissue homogenates, cell lysates and other biological fluids.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Aldehyde Dehydrogenase 7 Family Member A1 (ALDH7A1)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Test Range
0.156 ng/ml - 10 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-15 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q64057
Alias
ALDH7A1,ATQ1
Background
Elisa Kits for: ALDH7A1
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Descripción

ALDH7A1, also known as antiquitin, is a multifunctional enzyme involved in lysine catabolism and aldehyde detoxification. It catalyzes the oxidation of α-aminoadipic semialdehyde to α-aminoadipate, a key step in the lysine degradation pathway. Mutations in ALDH7A1 cause pyridoxine-dependent epilepsy (PDE), a rare inherited disorder characterized by seizures that are responsive to vitamin B6 (pyridoxine) supplementation. ALDH7A1 deficiency leads to the accumulation of toxic intermediates, such as α-aminoadipic semialdehyde, which interfere with neurotransmitter function and neuronal health. ALDH7A1 also plays a role in detoxifying aldehydes generated during lipid peroxidation and oxidative stress, protecting tissues from damage. Its expression in the liver, brain, and kidneys highlights its importance in amino acid metabolism, energy production, and cellular defense against aldehyde toxicity.

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