Rat Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) ELISA Kit
715€ (96 tests)
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name
Rat Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx517438
tested applications
ELISA
Description
Rat Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Aldehyde Dehydrogenase 4 Family, Member A1 (ALDH4A1) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.19 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P0C2X9 |
| Alias | P5C dehydrogenase |
| Background | Elisa Kits for: ALDH4A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
ALDH4A1, also known as pyrroline-5-carboxylate dehydrogenase (P5CDH), is a mitochondrial enzyme that catalyzes the conversion of pyrroline-5-carboxylate (P5C) into glutamate as part of the proline degradation pathway. This reaction is critical for maintaining amino acid metabolism, nitrogen balance, and cellular energy production. ALDH4A1 is expressed in tissues such as the liver, kidneys, and muscles, where proline serves as a key energy substrate. Mutations in ALDH4A1 lead to hyperprolinemia type II, a rare metabolic disorder characterized by elevated levels of proline and P5C, causing neurological symptoms, seizures, and cognitive impairments. ALDH4A1 also plays a role in protecting cells from oxidative stress, as proline metabolism generates NADH, which supports mitochondrial function. Its regulation is critical for amino acid catabolism, energy balance, and stress responses under nutrient deprivation.
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Human ALDH4A1 (Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial) ELISA Kit
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ALDH4A1 antibody
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
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