Rat Adrenocorticotropic Hormone Receptor (ACTHR) Protein

Product specifications

Proteins and Peptides

Adrenocorticotropic Hormone Receptor (ACTHR)

E. coli

Rat

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

MC2R,ACTHR,melanocortin 2 receptor,adrenocorticotropic hormone receptor,melanocortin 2 receptor (adrenocorticotropic hormone)

Protein MC2R

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

MC2R, also known as the adrenocorticotropic hormone receptor, is a G protein-coupled receptor specifically activated by adrenocorticotropic hormone (ACTH). MC2R is primarily expressed in the adrenal cortex, where it regulates the synthesis and release of glucocorticoids, such as cortisol, in response to ACTH binding. Upon activation, MC2R couples to Gs proteins, stimulating adenylyl cyclase and increasing cAMP levels, which activate protein kinase A (PKA). This signaling cascade drives steroidogenesis by upregulating key enzymes involved in cortisol production. MC2R is essential for maintaining the hypothalamic-pituitary-adrenal (HPA) axis, which controls the body’s response to stress, inflammation, and metabolism. Dysregulation of MC2R signaling is linked to conditions such as Addison’s disease (adrenal insufficiency), Cushing’s syndrome (excess cortisol), and ACTH resistance syndromes. Mutations in MC2R can impair cortisol production, leading to glucocorticoid deficiencies. Targeting MC2R and ACTH pathways offers therapeutic opportunities for managing adrenal disorders and inflammatory conditions involving glucocorticoid regulation.

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