Rat Adrenergic Receptor Beta 3 (ADRB3) Protein
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Description
Rat Adrenergic Receptor Beta 3 (ADRb3) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Adrenergic Receptor Beta 3 (ADRb3) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.6 kDa Observed MW: 22 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe195-Thr400 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ADRB3,atypical β-adrenoceptor,ADRB,Adrb-3,beta 3-AR,BETA3AR |
| Background | Protein ADRB3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The adrenergic receptor beta-3 (ADRB3) is a member of the beta-adrenergic receptor family, which is primarily expressed in adipose tissue, particularly brown and white fat, as well as in the bladder and vascular tissues. This G-protein-coupled receptor (GPCR) plays a critical role in regulating lipolysis and thermogenesis by activating adenylate cyclase through the Gs protein. Upon stimulation by catecholamines like norepinephrine and epinephrine, ADRB3 enhances energy expenditure, making it a key target in the management of obesity and metabolic syndrome. Its involvement in thermogenesis is mediated through the activation of uncoupling protein 1 (UCP1) in brown adipose tissue, which dissipates energy as heat. Polymorphisms in the ADRB3 gene, such as the Trp64Arg variant, have been associated with altered receptor activity, contributing to metabolic conditions like obesity, insulin resistance, and type 2 diabetes. Additionally, ADRB3 is implicated in bladder relaxation, making it a therapeutic target for overactive bladder syndrome. Its dual role in energy metabolism and smooth muscle relaxation underscores its significance in systemic metabolic regulation and pharmaceutical research.
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