Rat Adrenergic Receptor Beta 3 (ADRB3) CLIA Kit
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Description
Rat Adrenergic Receptor beta 3 (ADRb3) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates and other biological fluids.
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Product specifications
| Category | CLIA Kits |
| Immunogen Target | Adrenergic Receptor Beta 3 (ADRB3) |
| Reactivity | Rat |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.062 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ADRB3,atypical β-adrenoceptor,ADRB,Adrb-3,beta 3-AR,BETA3AR |
| Background | CLIA Kits ADRB3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The adrenergic receptor beta-3 (ADRB3) is a member of the beta-adrenergic receptor family, which is primarily expressed in adipose tissue, particularly brown and white fat, as well as in the bladder and vascular tissues. This G-protein-coupled receptor (GPCR) plays a critical role in regulating lipolysis and thermogenesis by activating adenylate cyclase through the Gs protein. Upon stimulation by catecholamines like norepinephrine and epinephrine, ADRB3 enhances energy expenditure, making it a key target in the management of obesity and metabolic syndrome. Its involvement in thermogenesis is mediated through the activation of uncoupling protein 1 (UCP1) in brown adipose tissue, which dissipates energy as heat. Polymorphisms in the ADRB3 gene, such as the Trp64Arg variant, have been associated with altered receptor activity, contributing to metabolic conditions like obesity, insulin resistance, and type 2 diabetes. Additionally, ADRB3 is implicated in bladder relaxation, making it a therapeutic target for overactive bladder syndrome. Its dual role in energy metabolism and smooth muscle relaxation underscores its significance in systemic metabolic regulation and pharmaceutical research.
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