Rat Activin A Receptor Type 1 (ACVR1) Protein
1716€ (200 µg)
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935106861
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name
Rat Activin A Receptor Type 1 (ACVR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691180
tested applications
SDS-PAGE
Description
Rat ALK-2 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat ACVR1 (P80201) (Met1-Glu123) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | ALK-2 |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 38.5 kDa Sequence Fragment: Met1-Glu123 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 200 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P80201 |
| Alias | ACVRLK2 |
| Background | Protein ACVR1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.
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