Rat Activin A Receptor Type 1 (ACVR1) Protein

Este producto es parte de ACVR - Activin A Receptor Type
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1716€ (200 µg)

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935106861
info@markelab.com
name
Rat Activin A Receptor Type 1 (ACVR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691180
tested applications
SDS-PAGE

Description

Rat ALK-2 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat ACVR1 (P80201) (Met1-Glu123) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
ALK-2
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 38.5 kDa
Sequence Fragment: Met1-Glu123
Tag: C-terminal Fc tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
200 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P80201
Alias
ACVRLK2
Background
Protein ACVR1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ACVR1, also called ALK2 (Activin Receptor-Like Kinase 2), is a transmembrane serine/threonine kinase receptor. It binds ligands like BMPs (Bone Morphogenetic Proteins), initiating intracellular SMAD signaling. This receptor plays a crucial role in bone development, embryogenesis, and organogenesis. Mutations in ACVR1 are linked to fibrodysplasia ossificans progressiva (FOP), a rare disorder where soft tissues progressively ossify. Structurally, it comprises an extracellular ligand-binding domain, a single transmembrane helix, and an intracellular kinase domain.

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