Ras-related protein Rab-8A (RAB8A) Antibody

Background

RAB8A, member RAS oncogene family (RAB8A) is a small GTPase involved in regulating intracellular vesicular trafficking, specifically in the transport of vesicles from the Golgi apparatus to the plasma membrane RAB8A is essential for the trafficking of membrane proteins, such as receptors and transporters, and is crucial for the maintenance of cell polarity and membrane dynamics It plays a role in regulating processes like cytokinesis, ciliogenesis, and the establishment of cellular structures by controlling vesicle movement to different regions of the plasma membrane Additionally, RAB8A has been shown to influence neural development and synaptic vesicle trafficking in neurons Dysregulation of RAB8A is associated with several diseases, including neurodegenerative conditions, where its disruption can impair vesicular trafficking and lead to cellular dysfunction RAB8A's involvement in cell signaling, cell cycle regulation, and membrane trafficking also positions it as an important factor in cancer biology and cellular migration