Ras-related protein Rab-8A (RAB8A) Antibody
260€ (50 µl)
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Name
Ras-related protein Rab-8A (RAB8A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx241992
Tested Applications
ELISA, WB, IHC
Description
RAB8A Antibody is a Rabbit Polyclonal against RAB8A.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Ras-related protein Rab-8A (RAB8A) Immunogen: Synthetic peptide of human RAB8A. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P61006 |
| Gene ID | 4218 |
| Alias | Oncogene c-mel,MEL, RAB8,Ras-related protein Rab-8A |
| Background | Antibody anti-RAB8A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB8A, member RAS oncogene family (RAB8A) is a small GTPase involved in regulating intracellular vesicular trafficking, specifically in the transport of vesicles from the Golgi apparatus to the plasma membrane RAB8A is essential for the trafficking of membrane proteins, such as receptors and transporters, and is crucial for the maintenance of cell polarity and membrane dynamics It plays a role in regulating processes like cytokinesis, ciliogenesis, and the establishment of cellular structures by controlling vesicle movement to different regions of the plasma membrane Additionally, RAB8A has been shown to influence neural development and synaptic vesicle trafficking in neurons Dysregulation of RAB8A is associated with several diseases, including neurodegenerative conditions, where its disruption can impair vesicular trafficking and lead to cellular dysfunction RAB8A's involvement in cell signaling, cell cycle regulation, and membrane trafficking also positions it as an important factor in cancer biology and cellular migration
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