Ras-Related protein Rab-35 (RAB35) Antibody (Biotin)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
RAB35 Antibody (Biotin) is a Rabbit Polyclonal against RAB35 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ras-Related protein Rab-35 (RAB35) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15286 |
| Gene ID | 11021 |
| NCBI Accession | NP_001161078.1, NM_001167606.1, NP_006852.1, NM_006861.6 |
| OMIM | 604199 |
| Alias | RAY,H-ray,RAB1C,Ras-related protein Rab-1C,GTP-binding protein RAY,Ras-related protein Rab-35 |
| Background | Antibody anti-RAB35 |
| Status | RUO |
Descripción
RAB35, member RAS oncogene family (RAB35) is a small GTPase involved in regulating endocytosis, vesicle trafficking, and membrane recycling in the cell It plays an essential role in the trafficking of cellular membranes and proteins, particularly in the sorting of endosomal cargo for recycling or degradation RAB35 is also crucial in the regulation of autophagy, where it helps in the formation of autophagosomes for the degradation of dysfunctional cellular components This GTPase is involved in cellular signaling by modulating the movement of receptors and other signaling molecules to and from the cell membrane, thus influencing cell communication, adhesion, and migration RAB35’s dysfunction can result in impaired cellular homeostasis, contributing to diseases such as cancer, where disrupted vesicular trafficking supports uncontrolled cell growth and metastasis Moreover, defects in RAB35 are also linked to neurodegenerative conditions, where defective vesicular trafficking leads to cellular stress and dysfunction
Related Products
RAB35 antibody
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate(PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.
Ver Producto
Recombinant Human RAB35
Ver Producto
Rab35, Member Ras Oncogene Family (RAB35) Antibody
Rab35, Member Ras Oncogene Family Antibody is a Rabbit Polyclonal antibody against Rab35, Member Ras Oncogene Family.
Ver Producto