Ras-Related Protein Rab-10 (RAB10) Antibody

Product specifications

Primary Antibodies

Ras-Related Protein Rab-10 (RAB10)

Mouse

Human, Mouse

ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG1

Unpurified ascites.

100 µl

Liquid

ELISA, WB, IF/ICC

Ascitic fluid containing 0.03% sodium azide.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P61026

10890

Ras-related protein Rab-10

Antibody anti-RAB10

RUO

Concentration: Not determined. -

Descripción

RAB10, member RAS oncogene family (RAB10) is a member of the small GTPase family, which plays an essential role in regulating intracellular vesicular trafficking and membrane dynamics RAB10 is particularly crucial in the regulation of vesicle transport from the Golgi to the plasma membrane, helping to control the proper trafficking of proteins and lipids across various cellular compartments It is involved in processes such as exocytosis, endocytosis, and the recycling of membrane proteins, thus ensuring the continuous supply of necessary components to the cell surface RAB10’s role in cellular functions extends beyond vesicular trafficking, as it also regulates the actin cytoskeleton and is essential for maintaining cell shape, polarity, and motility It is particularly significant in the regulation of cell migration and adhesion by controlling the movement of integrins, which are critical for the attachment of cells to their extracellular matrix RAB10 is also involved in the regulation of glucose uptake, especially in adipocytes and muscle cells, in response to insulin signaling, making it crucial for metabolic regulation and insulin sensitivity Disruption in RAB10’s function has been linked to diseases such as cancer, where abnormal cell migration and adhesion contribute to tumor invasion and metastasis, as well as type 2 diabetes, where impaired glucose uptake leads to metabolic dysfunction The significance of RAB10 in both metabolic and cellular signaling pathways underscores its importance as a potential therapeutic target for metabolic disorders and cancers

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