Rabbit Tissue Factor Pathway Inhibitor (TFPI) Protein
429€ (50 µg)
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name
Rabbit Tissue Factor Pathway Inhibitor (TFPI) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069320
tested applications
WB, SDS-PAGE
Description
Recombinant Tissue Factor Pathway Inhibitor (TFPI) is a recombinant Rabbit protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Tissue Factor Pathway Inhibitor (TFPI) |
| Host | E. coli |
| Origin | Rabbit |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 57.2 kDa Observed MW (SDS-PAGE): 58 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys39-Gly275 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19761 |
| Alias | EPI, LACI, TFI, TFPI1,Extrinsic pathway inhibitor,EPI |
| Background | Protein TFPI |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Tissue Factor Pathway Inhibitor (TFPI) is a crucial regulator of the extrinsic coagulation cascade, primarily inhibiting the tissue factor (TF)-factor VIIa complex and factor Xa to maintain hemostasis and prevent excessive thrombosis. It is a Kunitz-type serine protease inhibitor, produced mainly by endothelial cells, and circulates bound to lipoproteins or as a free plasma protein. TFPI acts as a feedback inhibitor that ensures balanced thrombin generation, thereby reducing the risk of pathological clot formation. Dysregulation or deficiency in TFPI has been linked to thrombotic disorders and cardiovascular diseases. Beyond its anticoagulant role, TFPI exhibits anti-inflammatory properties, reducing vascular inflammation and protecting against atherosclerosis. It is also involved in angiogenesis and endothelial cell function, making it significant in vascular biology.
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