Rabbit Tissue Factor Pathway Inhibitor (TFPI) Protein
Pida mas información
935106861
info@markelab.com
Precio
429€ (50 µg)
Protein TFPI
proveedor
Abbexareference
abx069320Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Tissue Factor Pathway Inhibitor (TFPI) is a recombinant Rabbit protein produced in a Prokaryotic expression system (E. coli).
Background
Tissue Factor Pathway Inhibitor (TFPI) is a crucial regulator of the extrinsic coagulation cascade, primarily inhibiting the tissue factor (TF)-factor VIIa complex and factor Xa to maintain hemostasis and prevent excessive thrombosis. It is a Kunitz-type serine protease inhibitor, produced mainly by endothelial cells, and circulates bound to lipoproteins or as a free plasma protein. TFPI acts as a feedback inhibitor that ensures balanced thrombin generation, thereby reducing the risk of pathological clot formation. Dysregulation or deficiency in TFPI has been linked to thrombotic disorders and cardiovascular diseases. Beyond its anticoagulant role, TFPI exhibits anti-inflammatory properties, reducing vascular inflammation and protecting against atherosclerosis. It is also involved in angiogenesis and endothelial cell function, making it significant in vascular biology.
Características del producto
category
Proteins and Peptides
origin
Rabbit
host
E. coli
immunogen target
Tissue Factor Pathway Inhibitor (TFPI)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 57.2 kDa Observed MW (SDS-PAGE): 58 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys39-Gly275 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TFPI
dry ice
No
availability
Shipped within 5-7 working days.
alias
EPI, LACI, TFI, TFPI1,Extrinsic pathway inhibitor,EPI
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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