Rabbit Tissue Inhibitors Of Metalloproteinase 3 (TIMP3) Protein is a Recombinant Rabbit protein expressed in E. coli.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP-3 (Tissue Inhibitor of Metalloproteinases 3) serves as a natural inhibitor of matrix metalloproteinases (MMPs). It has the ability to form complexes with various metalloproteinases, including collagenases, and inactivates them irreversibly by binding to their catalytic zinc cofactor. This binding effectively halts the enzymatic activity of these MMPs. TIMP-3 is known to act on several MMPs, including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14, and MMP-15. Its role in forming tissue-specific acute responses to remodeling stimuli underscores its importance in regulating extracellular matrix dynamics and tissue maintenance.
Proteins and Peptides
Rabbit
E. coli
Metalloproteinase Inhibitor 3 (TIMP3)
E. coli
Unconjugated
Lyophilized
WB, SDS-PAGE
1 mg
5 mg
Recombinant
> 90%
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
TIMP3
No
Shipped within 1-2 months.
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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