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Rabbit Matrix Metalloproteinase 9 (MMP9) ELISA Kit
proveedor
Abbexareference
abx575233Tested Applications
ELISAreactivity
Rabbitstatus
RUOclonality
Descripción
Rabbit Matrix Metalloproteinase 9 (MMP9) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rabbit MMP9 concentrations in serum, plasma and other biological fluids.
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. MMP-9, alternatively known as 92 kDa type IV collagenase, 92 kDa gelatinase, or gelatinase B (GELB), belongs to the zinc-metalloproteinases within the Matrixin family. In humans, the MMP-9 gene is responsible for encoding this enzyme. MMP-9's substrates include gelatin and collagen types IV and V. This gelatinase, MMP-9, has been associated with various medical conditions, including the development of atherosclerosis, chronic obstructive pulmonary disease (COPD), tumor formation, metastasis, and wound repair
Background
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. MMP-9, también conocida como colagenasa tipo IV de 92 kDa, gelatinasa de 92 kDa o gelatinasa B (GELB), pertenece a las metaloproteinasas de zinc dentro de la familia Matrixin. En humanos, el gen MMP-9 es el responsable de codificar esta enzima. Los sustratos de MMP-9 incluyen gelatina y colágeno de tipos IV y V. Esta gelatinasa, MMP-9, se ha asociado con diversas afecciones médicas, incluido el desarrollo de aterosclerosis, enfermedad pulmonar obstructiva crónica (EPOC), formación de tumores, metástasis y reparación de heridas
Características del producto
category
ELISA Kits
immunogen target
Matrix Metalloproteinase 9 (MMP9)
reactivity
Rabbit
test range
3.125 ng/ml - 200 ng/ml
sensitivity
1.88 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
alias
GELB,CLG4B,MMP-9,MANDP2,92 kDa type IV collagenase, Gelatinase B
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
MMP9
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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