Rabbit Matrix Metalloproteinase 1 (MMP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rabbit MMP1 concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of MMP1No significant cross-reactivity or interference between MMP1 and analogues was observed.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Interstitial collagenase, also recognized as matrix metalloproteinase-1 (MMP-1), is an enzyme encoded by the MMP1 gene in humans. This enzyme, when secreted, serves to degrade interstitial collagens, including types I, II, and III. It is also known by aliases such as CLG and CLGN
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La colagenasa intersticial, también reconocida como metaloproteinasa de matriz-1 (MMP-1), es una enzima codificada por el gen MMP1 en humanos. Esta enzima, cuando se secreta, sirve para degradar los colágenos intersticiales, incluidos los tipos I, II y III. También se le conoce con alias como CLG y CLGN
ELISA Kits
Matrix Metalloproteinase 1 (MMP1)
Rabbit
0.312 ng/ml - 20 ng/ml
< 0.13 ng/ml
Sandwich
Quantitative
Colorimetric
Serum,Plasma,Other biological fluids
96 tests
5 × 96 tests
10 × 96 tests
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
MMP1
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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