Human Ras-Related Protein Rab-3A (RAB3A) Protein
234€ (2 µg)
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Name
Human Ras-Related Protein Rab-3A (RAB3A) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx262903
Tested Applications
SDS-PAGE
Description
Ras-Related Protein Rab-3A (RAB3A) is a recombinant protein consisting of a single, non-glycosylated polypeptide chain containing 240 amino acids, expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Ras-Related Protein Rab-3A (RAB3A) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 1-220 AA. Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 27.1 kDa |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) <br> Sterile filtered. |
| Purification | Purified by proprietary chromatography techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl, pH 8.0, containing 20% Glycerol, 0.1 M NaCl and 1 mM DTT. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C for up to 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20336 |
| Alias | Ras-related protein Rab-3A,RAS-associated protein RAB3A |
| Background | Protein RAB3A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 0.5 mg/ml |
Background
RAB3A, member RAS oncogene family (RAB3A) is another small GTPase that is primarily involved in regulating vesicular trafficking, particularly in neurons and endocrine cells RAB3A plays a pivotal role in the regulated release of neurotransmitters and hormones through its involvement in synaptic vesicle recycling and exocytosis It is essential for the proper functioning of synapses, where it helps control the fusion of synaptic vesicles with the plasma membrane, allowing for neurotransmitter release and signal transmission between neurons In addition to its function in neurotransmission, RAB3A is also involved in insulin secretion in pancreatic beta cells Dysregulation of RAB3A is associated with neurological disorders, such as epilepsy and neurodegenerative diseases, as well as metabolic disorders like diabetes, where impaired vesicle trafficking and hormone release contribute to disease progression Understanding RAB3A’s role in cellular transport and neurotransmission is critical for developing therapeutic strategies for neurological and metabolic diseases
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