RAB27B, Member RAS Oncogene Family (RAB27B) Antibody
169€ (20 µl)
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935106861
info@markelab.com
name
RAB27B, Member RAS Oncogene Family (RAB27B) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx321343
tested applications
ELISA, IHC
Description
RAB27B Antibody is a Rabbit Polyclonal against RAB27B.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB27B, Member RAS Oncogene Family (RAB27B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00194 |
| Gene ID | 5874 |
| OMIM | 603869 |
| Alias | C25KG,Ras-related protein Rab-27B |
| Background | Antibody anti-RAB27B |
| Status | RUO |
Descripción
RAB27B, member RAS oncogene family (RAB27B) is a small GTPase that plays a significant role in intracellular vesicular trafficking, particularly in the movement of secretory vesicles to the plasma membrane It is involved in regulating the exocytosis of lysosome-related organelles, such as melanosomes and secretory granules, which are critical for processes like pigmentation and immune cell function RAB27B regulates the trafficking of proteins and lipids, ensuring proper cellular function and membrane recycling It also plays a role in cell adhesion and migration by controlling the delivery of integrins and other cell surface proteins In immune cells, RAB27B is important for cytotoxic T lymphocyte function, contributing to the release of cytotoxic granules that target and destroy infected or cancerous cells Dysregulation of RAB27B is associated with several diseases, including Griscelli syndrome and autoimmune conditions, where defects in vesicular trafficking impair immune response, pigmentation, and organ function RAB27B also has implications in cancer progression, where altered vesicular trafficking contributes to tumor invasion and metastasis
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