RAB1B, Member RAS Oncogene Family Protein

Background

RAB1B, member RAS oncogene family (RAB1B) is a GTPase closely related to RAB1A and shares many functional similarities in regulating intracellular transport and vesicular trafficking RAB1B is involved in the trafficking of proteins from the ER to the Golgi, as well as the maintenance of membrane integrity and the regulation of cell growth RAB1B helps coordinate the transport of vesicles carrying cargo such as lipids and enzymes, playing a vital role in processes like protein secretion and receptor recycling Like RAB1A, RAB1B is also involved in regulating the organization of the Golgi apparatus and facilitating communication between the ER and Golgi in secretory cells Dysregulation of RAB1B has been associated with cancer, where abnormal vesicular trafficking can promote tumor growth and metastasis Additionally, RAB1B has been implicated in certain viral infections, where it aids in the cellular entry and replication of viruses, further emphasizing its relevance in both cellular function and disease