RAB11B, Member RAS Oncogene Family (RAB11B) Antibody (Biotin)
169€ (20 µg)
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Name
RAB11B, Member RAS Oncogene Family (RAB11B) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx306859
Tested Applications
ELISA
Description
RAB11B Antibody (Biotin) is a Rabbit Polyclonal against RAB11B conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: RAB11B, Member RAS Oncogene Family (RAB11B) Immunogen: Recombinant human Ras-related protein Rab-11B protein (2-215AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15907 |
| Gene ID | 9230 |
| NCBI Accession | NP_004209.2, NM_004218.3 |
| OMIM | 604198 |
| Alias | YPT3,GTP-binding protein YPT3,Ras-related protein Rab-11B |
| Background | Antibody anti-RAB11B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
RAB11B, member RAS oncogene family (RAB11B) is closely related to RAB11A and shares many functions in regulating intracellular vesicular trafficking, particularly in the recycling of endosomal vesicles and the transport of membrane proteins between the late endosomes and the recycling endosomes RAB11B plays a central role in ensuring proper receptor recycling, which is important for maintaining the homeostasis of cell surface protein expression and regulating cell signaling processes, including growth, differentiation, and adhesion It contributes to various cellular functions such as vesicle trafficking, cytokinesis, and microtubule organization, particularly during cell division, ensuring proper vesicle distribution and cytokinesis Furthermore, RAB11B is involved in regulating immune responses, as it affects the trafficking of immune receptors and cytokines, impacting immune cell signaling and function Disruptions in RAB11B’s function are implicated in a wide range of diseases, particularly in cancer, where defective vesicular trafficking leads to altered receptor availability, facilitating uncontrolled cell growth and metastasis Additionally, RAB11B is implicated in neurological diseases, where impairments in vesicular recycling and receptor trafficking contribute to neuronal dysfunction, as well as in metabolic diseases such as obesity and type 2 diabetes, where changes in glucose uptake and insulin sensitivity are associated with altered vesicle trafficking pathways
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