RAB11 Antibody
364€ (100 µg)
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name
RAB11 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx236988
tested applications
ELISA, WB, IHC, IF/ICC, IP
Description
RAB11 Antibody is a Rabbit Polyclonal against RAB11.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RAB11 |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/50 - 1/500, IF/ICC: 1/50 - 1/500, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P62491 |
| Alias | RAB11,YL8,Ras-related protein Rab-11A |
| Background | Antibody anti-RAB11A |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
RAB11A, member RAS oncogene family (RAB11A) is a highly conserved small GTPase that is integral to regulating intracellular vesicle trafficking, particularly in the recycling of endosomal components and maintaining the integrity of the Golgi apparatus RAB11A is involved in several key processes, such as the recycling of internalized receptors back to the plasma membrane, which is essential for regulating cell surface protein levels and maintaining normal receptor function This function makes RAB11A crucial for cellular signaling, as it modulates the availability of signaling receptors on the cell surface, impacting processes like growth factor signaling, immune responses, and neurotransmitter receptor regulation Additionally, RAB11A contributes to the organization and function of the microtubule network, which is vital for cell division, polarity, and maintaining cellular structure It is also involved in the proper organization of the actin cytoskeleton, which is important for maintaining cell shape and facilitating cellular movements such as migration and adhesion RAB11A has been implicated in several diseases, including cancer, where dysregulated vesicular trafficking and altered receptor recycling contribute to tumor growth, metastasis, and resistance to therapy Additionally, RAB11A’s role in the immune response and inflammatory signaling pathways makes it an important regulator of immune function Disruption in RAB11A’s activity can have significant consequences for cellular homeostasis, making it a critical factor in both healthy cellular processes and disease pathogenesis
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RAB11 has two isoform genes RAB11A(YL8) and RAB11B(YPT3), and belongs to the small GTPase superfamily and Rab family. It regulates endocytic recycling. RAB11 may exert its functions by interacting with multiple effector proteins in different complexes. It acts as a major regulator of membrane delivery during cytokinesis. RAB11 regulates the recycling of FCGRT(receptor of Fc region of monomeric Ig G) to basolateral membranes. This antibody can recognize both RAB11A(24kd) and RAB11B(24kd).
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