Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
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Description
Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody is a Rabbit Polyclonal antibody for the detection of CHM.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Immunogen: Rab proteins geranylgeranyltransferase component A 1 |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 100 kDa, 60 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24386 |
| Gene ID | 1121 |
| Background | Antibody anti-CHM |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
CHM Antibody is a Rabbit Polyclonal Antibody against CHM.
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Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
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