PYD And CARD Domain Containing (Pycard) Antibody

Este producto es parte de PYCARD - PYD and CARD domain containing
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442€ (200 µl)

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935106861
info@markelab.com
name
PYD And CARD Domain Containing (Pycard) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432082
tested applications
P-ELISA, IF/ICC

Description

Pycard Antibody is a Goat Polyclonal antibody against Pycard.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Target: PYD And CARD Domain Containing (Pycard)
Immunogen: abx617039 - Internal region: C-DLTDKLVSYYLES
Host
Goat
Reactivity
Human, Mouse, Rat
Assay Type
Concentration: 0.5 mg/ml
Recommended Dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, IF/ICC
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
29108, 66824, 282817
NCBI Accession
NP_075747.3
Alias
ASC, CARD5, TMS, TMS-1, TMS1,Apoptosis-associated speck-like protein containing a CARD
Background
Antibody anti-PYCARD
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

PYD and CARD domain containing (PYCARD), also known as ASC (apoptosis-associated speck-like protein containing a CARD), is a bipartite adaptor protein involved in innate immunity and inflammation PYCARD contains both a PYRIN domain (PYD) and a caspase recruitment domain (CARD), which facilitate its interaction with inflammasome components such as NLRP3 and caspase-1 PYCARD is essential for inflammasome assembly, leading to the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 and induces pyroptosis, a form of inflammatory cell death Dysregulation of PYCARD has been implicated in inflammatory diseases such as gout, where it activates inflammasomes in response to uric acid crystals, and in autoimmune disorders including lupus PYCARD is also involved in apoptosis, interacting with pro-apoptotic factors to regulate programmed cell death Its overactivation or suppression has been associated with cancer, neuroinflammation, and metabolic diseases, highlighting its critical role in balancing inflammation and cell survival
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