Proto-Oncogene Vav (VAV1) Protein
234€ (2 µg)
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Name
Proto-Oncogene Vav (VAV1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx263391
Tested Applications
SDS-PAGE
Description
VAV1 is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | VAV1 |
| Assay Type | Activity: Not tested |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P15498 |
| Alias | VAV1, VAV,VAV1 protein,Proto-oncogene vav |
| Background | Protein VAV1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
VAV1 is a guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, such as Rac1 and Cdc42, by facilitating the exchange of GDP for GTP. It is primarily expressed in hematopoietic cells, where it plays a critical role in T-cell receptor (TCR) and B-cell receptor (BCR) signaling, cytoskeletal rearrangement, and immune cell activation. VAV1 acts as a signaling scaffold, linking tyrosine kinases to downstream effectors that regulate cell migration, adhesion, and polarization. It is essential for lymphocyte development, antigen receptor signaling, and immune responses. Dysregulation of VAV1 is associated with autoimmune diseases, impaired immune cell function, and certain cancers, including T-cell leukemia, where it promotes abnormal proliferation and survival. Knockout studies reveal defects in T-cell activation, impaired immune responses, and defective cytoskeletal organization, highlighting its critical role in immune signaling, cytoskeletal dynamics, and lymphocyte function.
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