Proto-Oncogene Vav (VAV1) Cell ELISA Kit
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Description
VAV1 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Proto-Oncogene Vav (VAV1) |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P15498 |
| Gene ID | 7409 |
| OMIM | 164875 |
| Alias | VAV1, VAV,VAV1 protein,Proto-oncogene vav |
| Background | Elisa kits for VAV1 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
VAV1 is a guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, such as Rac1 and Cdc42, by facilitating the exchange of GDP for GTP. It is primarily expressed in hematopoietic cells, where it plays a critical role in T-cell receptor (TCR) and B-cell receptor (BCR) signaling, cytoskeletal rearrangement, and immune cell activation. VAV1 acts as a signaling scaffold, linking tyrosine kinases to downstream effectors that regulate cell migration, adhesion, and polarization. It is essential for lymphocyte development, antigen receptor signaling, and immune responses. Dysregulation of VAV1 is associated with autoimmune diseases, impaired immune cell function, and certain cancers, including T-cell leukemia, where it promotes abnormal proliferation and survival. Knockout studies reveal defects in T-cell activation, impaired immune responses, and defective cytoskeletal organization, highlighting its critical role in immune signaling, cytoskeletal dynamics, and lymphocyte function.
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