Protein Wnt-5a (Wnt5a) Antibody (Biotin)
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Description
Wnt5a Antibody (Biotin) is a Rabbit Polyclonal against Wnt5a.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Wnt-5a (Wnt5a) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC: 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Purification | Peptide Affinity Purified |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41221 |
| Gene ID | 7474 |
| NCBI Accession | NP_001243034.1 |
| Background | Antibody anti-Wnt5a |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Protein Wnt-5a (Wnt5a) Antibody
Wnt5a Antibody is a Rabbit Polyclonal antibody against Wnt5a. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
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Protein Wnt-5a (Wnt5a) Antibody
WNT5A Antibody is a Rabbit Polyclonal antibody against WNT5A. The Wnt family includes several secreted glycoproteins that play important roles in animal developmentThere are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteinsWnt members bind to the Frizzled family of seven-pass transmembrane proteins and activate several signaling pathwaysThe canonical Wnt/β-catenin pathway also requires a coreceptor from the low-density lipoprotein receptor familyAberrant activation of Wnt signaling pathways is involved in several types of cancersWnt-5a has been shown to signal through the canonical Wnt pathways as well as through non-canonical pathways and is up-regulated in various types of human cancersIn melanoma, WNT5A is thought to directly affect cell motility and metastasis.
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