Protein Tyrosine Phosphatase, Receptor Type R (PTPRR) Antibody
357.5€ (100 µg)
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935106861
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name
Protein Tyrosine Phosphatase, Receptor Type R (PTPRR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx122351
tested applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the PTPRR protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase, Receptor Type R (PTPRR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC122866 |
| Alias | PTPRQ,EC-PTP,PCPTP1,PTP-SL,PTPBR7,Protein-tyrosine phosphatase PCPTP1,Ch-1PTPase,NC-PTPCOM1,R-PTP-R,Receptor-type tyrosine-protein phosphatase R |
| Background | Antibody anti-PTPRR |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
PTPRR is a receptor-type protein tyrosine phosphatase involved in regulating signal transduction pathways critical for neuronal function and development. Structurally, PTPRR contains a single transmembrane domain and an intracellular phosphatase domain. It is primarily expressed in the central nervous system (CNS), particularly in the brain and cerebellum. PTPRR is involved in modulating mitogen-activated protein kinase (MAPK) signaling by dephosphorylating and inactivating ERK1/2, thereby regulating neuronal differentiation, synaptic plasticity, and signal propagation. PTPRR isoforms differ in size and localization due to alternative splicing, including membrane-bound and cytosolic forms. Mutations or dysregulation of PTPRR have been associated with neurological disorders such as ataxia and cognitive deficits. PTPRR also participates in cellular responses to external stimuli by modulating kinase activity. Its regulatory role in neuronal signaling underscores its importance in brain development, synaptic transmission, and neurodegenerative disease processes.
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