Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Antibody

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
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351€ (100 µg)

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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375959
tested applications
ELISA, WB

Description

Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Antibody is a Rabbit Polyclonal antibody against Protein Tyrosine Phosphatase Receptor Type G (PTPRG).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type G (PTPRG)
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
ELISA: 1/5000 - 1/20000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by affinity chromatography using epitope-specific immunogen.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P23470
Gene ID
5793
OMIM
176886
Alias
PTPG,HPTPG,RPTPG,R-PTP-GAMMA,Protein-tyrosine phosphatase gamma,Receptor-type tyrosine-protein phosphatase gamma
Background
Antibody anti-PTPRG
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

PTPRG is a receptor-type protein tyrosine phosphatase that plays a key role in tumor suppression, immune regulation, and nervous system development. Structurally, PTPRG contains extracellular carbonic anhydrase-like and fibronectin type III domains, a transmembrane region, and two cytoplasmic phosphatase domains. PTPRG is expressed in various tissues, particularly in the brain and immune system. It regulates cellular signaling by dephosphorylating receptor tyrosine kinases (RTKs), thereby influencing cell proliferation, adhesion, and migration. PTPRG has been identified as a tumor suppressor gene in cancers such as lung, breast, and colorectal cancers. In addition, its involvement in synaptic plasticity and neuronal repair highlights its significance in neurobiology. Loss of PTPRG expression through methylation or mutations contributes to tumorigenesis and neurological disorders.

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