Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Antibody
819€ (1 ml)
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Name
Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx174283
Tested Applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Tyrosine Phosphatase Receptor Type G (PTPRG) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | PTPG,HPTPG,RPTPG,R-PTP-GAMMA,Protein-tyrosine phosphatase gamma,Receptor-type tyrosine-protein phosphatase gamma |
| Background | Antibody anti-PTPRG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRG is a receptor-type protein tyrosine phosphatase that plays a key role in tumor suppression, immune regulation, and nervous system development. Structurally, PTPRG contains extracellular carbonic anhydrase-like and fibronectin type III domains, a transmembrane region, and two cytoplasmic phosphatase domains. PTPRG is expressed in various tissues, particularly in the brain and immune system. It regulates cellular signaling by dephosphorylating receptor tyrosine kinases (RTKs), thereby influencing cell proliferation, adhesion, and migration. PTPRG has been identified as a tumor suppressor gene in cancers such as lung, breast, and colorectal cancers. In addition, its involvement in synaptic plasticity and neuronal repair highlights its significance in neurobiology. Loss of PTPRG expression through methylation or mutations contributes to tumorigenesis and neurological disorders.
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