Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Antibody
377€ (100 µg)
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Name
Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx236944
Tested Applications
ELISA, WB, IHC
Description
PTPRE Antibody is a Rabbit Polyclonal against PTPRE.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor-Type Tyrosine-Protein Phosphatase Epsilon (PTPRE) Immunogen: protein tyrosine phosphatase, receptor type, E |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 81 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23469 |
| Gene ID | 5791 |
| OMIM | 600926 |
| Alias | PTPE,HPTPE,R-PTP-EPSILON,Protein-tyrosine phosphatase epsilon,Receptor-type tyrosine-protein phosphatase epsilon |
| Background | Antibody anti-PTPRE |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRE is a receptor-like protein tyrosine phosphatase that plays essential roles in cellular signaling, particularly in hematopoietic and neuronal systems. Structurally, PTPRE exists as two isoforms: a transmembrane receptor-type protein (RPTPε) and a non-receptor, intracellular cytoplasmic form (cyt-PTPε). Both isoforms share a common catalytic domain but differ in localization and functional regulation. PTPRE is involved in modulating signaling pathways such as those mediated by Src family kinases, integrins, and MAPK pathways. It influences osteoclast differentiation, insulin signaling, and energy metabolism. In the nervous system, PTPRE regulates ion channel activity and neuronal excitability. Dysregulation of PTPRE has been linked to metabolic disorders, including insulin resistance, and its overexpression can contribute to oncogenic signaling pathways in certain cancers.
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