Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody (PE / Cyanine 7)

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
104€ (50 tests)

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935106861
info@markelab.com
name
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody (PE / Cyanine 7)
category
Primary Antibodies
provider
Abbexa
reference
abx229195
tested applications
FCM

Description

CD45 Antibody (PE / Cyanine 7) is a Mouse Monoclonal Antibody against CD45.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Conjugation
PE / Cyanine 7
Isotype
IgG2b Kappa
Size 1
50 tests
Size 2
100 tests
Size 3
200 tests
Tested Applications
FCM
Buffer
PBS with 0.05% Proclin300, 1% BSA.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P06800
Gene ID
19264
Alias
LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C
Background
Antibody anti-PTPRC
Status
RUO

Descripción

PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.

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