Protein Tyrosine Kinase 6 (PTK6) Antibody

Este producto es parte de PTK - protein tyrosine kinase
Protein Tyrosine Kinase 6 (PTK6) Antibody

Pida mas información

935106861

info@markelab.com

Precio

787.5€ (1 ml)

Antibody anti-PTK6

proveedor

Abbexa

reference

abx174281

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

This product is currently in development. The lead time for this product may be several months. Please contact us at info@markelab.com for an updated lead time before purchasing this product. Protein Tyrosine Kinase 6 (PTK6) Antibody is a Mouse Monoclonal antibody against Protein Tyrosine Kinase 6 (PTK6).


Background

Protein Tyrosine Kinase 6 (PTK6), also known as BRK (Breast Tumor Kinase), is a non-receptor tyrosine kinase that is predominantly expressed in epithelial tissues and involved in regulating cell growth, differentiation, and stress responses. PTK6 is structurally similar to Src family kinases but functions independently of membrane localization. It contains an SH3 domain, SH2 domain, and a tyrosine kinase domain. PTK6 is localized in both the nucleus and cytoplasm, where it regulates distinct signaling pathways. In normal epithelial cells, PTK6 regulates differentiation and maintenance of tissue integrity. However, in cancers, particularly breast, colorectal, and prostate cancer, PTK6 is frequently upregulated and promotes cell proliferation, migration, and survival. PTK6 enhances signaling through pathways such as STAT3, AKT, and ERK1/2, contributing to tumor progression. Interestingly, PTK6 can also act as a tumor suppressor under certain conditions by promoting cell differentiation. Beyond cancer, PTK6 is involved in stress responses, including DNA damage repair and oxidative stress resistance. Its dual role in cell survival and differentiation makes PTK6 a potential therapeutic target in oncology.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Protein Tyrosine Kinase 6 (PTK6)


host

Mouse


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by Protein A and Protein G affinity chromatography.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

PTK6


dry ice

No


availability

Please enquire.


alias

BRK,Breast tumor kinase, Tyrosine-protein kinase BRK


note

This product is for research use only.


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