Protein Tyrosine Kinase 2 Beta Phospho-Tyr402 (PTK2B pY402) Antibody
429€ (100 µl)
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935106861
info@markelab.com
name
Protein Tyrosine Kinase 2 Beta Phospho-Tyr402 (PTK2B pY402) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx333215
tested applications
ELISA, WB, IHC, IF/ICC
Description
PTK2B (pY402) Antibody is a Rabbit Polyclonal against PTK2B (pY402).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Kinase 2 Beta Phospho-Tyr402 (PTK2B pY402) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr402 |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14289 |
| Gene ID | 2185 |
| Alias | PKB,PTK,CAKB,FAK2,PYK2,CADTK,FADK2,RAFTK,Proline-rich tyrosine kinase 2,Related adhesion focal tyrosine kinase,Calcium-regulated non-receptor proline-rich tyrosine kinase, Cell adhesion kinase beta,CAK-beta,Calcium-dependent tyrosine kinase |
| Background | Antibody anti-PTK2B |
| Status | RUO |
Descripción
Protein Tyrosine Kinase 2 Beta (PTK2B), also known as Pyk2, is a cytoplasmic tyrosine kinase related to PTK2 but has distinct roles in calcium signaling, immune responses, and neuronal function. PTK2B is activated by increased intracellular calcium levels, G-protein-coupled receptors (GPCRs), and environmental stress. Structurally, PTK2B shares a similar architecture with PTK2, including an FERM domain, kinase domain, and focal adhesion targeting region, but has a unique sensitivity to calcium signaling. PTK2B regulates cytoskeletal dynamics, cell adhesion, and migration, particularly in immune cells and neurons. PTK2B is highly expressed in the nervous system and plays a pivotal role in synaptic plasticity, neuronal migration, and memory formation. Its overactivation has been linked to neurodegenerative diseases such as Alzheimer’s disease by modulating tau phosphorylation and beta-amyloid signaling. In the immune system, PTK2B influences macrophage activation, B-cell responses, and inflammatory signaling pathways. Dysregulation of PTK2B is also associated with certain cancers, where it promotes cell survival, invasion, and tumor progression. Targeting PTK2B is being explored for potential therapeutic interventions in cancer and neuroinflammation.
