Protein phosphatase 1D (PPM1D) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Protein phosphatase 1D (PPM1D) Antibody is a Mouse Monoclonal antibody for Protein phosphatase 1D (PPM1D).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein phosphatase 1D (PPM1D) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1-2 μg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Clone ID | G046 |
| Purification | Purified by protein-A affinity chromatography. |
| Size 1 | 0.1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | O15297 |
| Gene ID | 8493 |
| Background | Antibody anti-PPM1D |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Related Products
Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody
PPM1D Antibody is a Rabbit Polyclonal antibody against PPM1D. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Ver Producto
Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Ver Producto
Protein Phosphatase, Mg2+/Mn2+ Dependent 1D (PPM1D) Antibody
PPM1D is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. Expression of this PPM1D gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. The PPM1D gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
Ver Producto