Protein C Inhibitor (SERPINA5) Antibody (Biotin)
proveedor
Abbexareference
abx337056Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Protein C Inhibitor (SERPINA5) Antibody (Biotin) is a Rabbit Polyclonal against Protein C Inhibitor (SERPINA5).
Background
Inhibitory serpins have been shown to function in processes as diverse as DNA binding, chromatin condensation, immunoregulation ,apoptosis and haemostasis. Serpins are a broadly distributed protease inhibitors that use the conformational change as a mechanism of action. They are central in controlling many important proteolytic cascades. Phylogenetically Serpins superfamily organized in "Clades", named by letters. The following numbers shows the position in the glade. Serpin named as a SERPINXy, (where X is the clade and y is the number within that clade) many serpins also have alternative names from before this classification was proposed. Structuraly Serpinsare three β-sheets (A, B and C), 8-9 α-helices (termed hA-hI) and the reactive center known as reactive center loop (RCL). Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor that control the activity of protein C (anticoagulant). SERPINA5 binds glycosaminoglycans, phospholipids, and retinoic acid. Glycosaminoglycans and certain phospholipids can modulate its inhibitory activity and specificity.
Background
Se ha demostrado que las serpinas inhibidoras funcionan en procesos tan diversos como la unión al ADN, la condensación de cromatina, la inmunorregulación, la apoptosis y la hemostasia. Las serpinas son inhibidores de proteasas ampliamente distribuidos que utilizan el cambio conformacional como mecanismo de acción. Son fundamentales para controlar muchas cascadas proteolíticas importantes. Filogenéticamente superfamilia de Serpinas organizada en "Clados", nombradas por letras. Los siguientes números muestran la posición en el claro. Serpin nombrada como SERPINXy (donde X es el clado e y es el número dentro de ese clado). Muchas serpinas también tienen nombres alternativos antes de que se propusiera esta clasificación. Estructuralmente, las Serpins son tres láminas β (A, B y C), 8-9 hélices α (denominadas hA-hI) y el centro reactivo conocido como bucle del centro reactivo (RCL). El inhibidor de la proteína C (PCI, SERPINA5) es un inhibidor de la serina proteasa que controla la actividad de la proteína C (anticoagulante). SERPINA5 se une a los glucosaminoglicanos, los fosfolípidos y el ácido retinoico. Los glucosaminoglicanos y ciertos fosfolípidos pueden modular su actividad inhibidora y su especificidad.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Protein C Inhibitor (SERPINA5)
host
Rabbit
conjugation
Biotin
form
Liquid
tested applications
ELISA
purity
> 95%
purification
Purified by Protein G.
buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
size 1
20 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
1 mg
storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
or code
SERPINA5
dry ice
No
availability
Shipped within 5-10 working days.
alias
PCI,PAI3,PAI-3; PCI-B,PROCI,PLANH3,Plasma serine protease inhibitor,Plasminogen activator inhibitor 3,Protein C inhibitor,Serpin A5 Acrosomal serine protease inhibitor
uniprot id
note
This product is for research use only.
Quizá le pueda interesar
Recombinant Human Serpin A5
proveedor
FineTestreference
P4508Tested Applications
Western Blot，ELISAstatus
RUOPrecio a consultar
Ver másHuman Protein C Inhibitor (SERPINA5) ELISA Kit
proveedor
Abbexareference
abx152855Tested Applications
ELISAreactivity
Humanstatus
RUOHuman Protein C Inhibitor (SERPINA5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Protei...
687.5€ (96 tests)
Ver másHuman Protein C Inhibitor (SERPINA5) CLIA Kit
proveedor
Abbexareference
abx190304Tested Applications
CLIAreactivity
Humanstatus
RUOHuman Protein C Inhibitor (SERPINA5) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay ...
812.5€ (96 tests)
Ver más