Protein Argonaute-2 (AGO2) Antibody
299€ (50 µl)
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Name
Protein Argonaute-2 (AGO2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx402557
Tested Applications
ELISA, IF/ICC, FCM
Description
Protein Argonaute-2 (AGO2) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human AGO2.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Argonaute-2 (AGO2) Immunogen: A synthesized peptide derived from Human AGO2 |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IF/ICC: 1/50 - 1/200, FCM: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC, FCM |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UKV8 |
| Alias | CASC7,EIF2C2,LESKRES,LINC00980,PPD,Q10 |
| Background | Antibody anti-AGO2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGO2 is the most well-characterized and catalytically active member of the Argonaute family, playing a central role in the RISC complex. AGO2 binds miRNAs and small interfering RNAs (siRNAs) to mediate both translational repression and endonucleolytic cleavage (slicing) of target mRNAs. Its conserved PIWI domain is responsible for its slicer activity, enabling AGO2 to degrade complementary mRNA targets directly. AGO2 is highly expressed in many tissues and is involved in crucial cellular processes, including gene silencing, developmental regulation, and the cellular response to viral infections. Dysregulation of AGO2 contributes to various pathological conditions, including cancers, neurodegenerative diseases, and immune disorders, due to its impact on gene expression and miRNA/siRNA pathways. AGO2 is also being explored as a potential therapeutic target in RNA-based therapies.
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