Protein argonaute-1 (AGO1) Antibody (FITC)
260€ (50 µl)
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Name
Protein argonaute-1 (AGO1) Antibody (FITC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx349639
Description
Protein argonaute-1 (AGO1) Antibody (FITC) is a Rabbit Polyclonal antibody conjugated to FITC for the detection of Human AGO1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein argonaute-1 (AGO1) Immunogen: Recombinant Human Protein argonaute-1 protein (251-400 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 488 Excitation/Emission: 499/515 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Size 3 | 200 µl |
| Size 4 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UL18 |
| Gene ID | 26523 |
| OMIM | 606228 |
| Alias | Q99,EIF2C,hAgo1,EIF2C1,GERP95,NEDLBAS |
| Background | Antibody anti-AGO1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
AGO1 is a member of the Argonaute protein family, essential for the RNA-induced silencing complex (RISC), a key player in RNA interference (RNAi) and microRNA (miRNA)-mediated gene regulation. AGO1 primarily binds to miRNAs and facilitates the repression of target mRNA translation without significant endonucleolytic cleavage. Structurally, it contains conserved domains, including the PAZ domain, which binds the 3' end of small RNAs, and the PIWI domain, which has weak or no slicer activity in AGO1. AGO1 is expressed ubiquitously, with a role in post-transcriptional regulation in various biological processes, such as cell proliferation, differentiation, and stress responses. Dysregulation of AGO1 has been linked to diseases such as cancer and autoimmune disorders, where abnormal miRNA-mediated silencing affects critical pathways.
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