Programmed Cell Death Protein 1 (PDCD1) Antibody (PerCP / Cyanine 5.5)

Product specifications

Primary Antibodies

Programmed Cell Death Protein 1 (PDCD1)

Mouse

Human, Monkey

Monoclonal

PerCP / Cyanine 5.5

IgG1 Kappa

T972

100 tests

FCM

Stabilizing PBS solution containing 15 mM sodium azide.

Shipped within 5-12 working days.

Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.

No

Q15116

5133

Protein PD-1,PD1,PD-1,CD279,SLEB2,hPD-1,hPD-l,hSLE1,

Antibody anti-PDCD1

RUO

Descripción

Programmed cell death 1 (PDCD1), commonly referred to as PD-1, is a transmembrane protein and immune checkpoint receptor expressed primarily on the surface of T cells, B cells, and some myeloid cells. PD-1 is encoded by the PDCD1 gene and plays a pivotal role in regulating immune responses by inhibiting T-cell activation, particularly in peripheral tissues during inflammation. It serves as a checkpoint receptor that, when engaged, dampens the immune response, promoting self-tolerance and preventing autoimmune reactions. PD-1 binds to its ligands, PD-L1 (CD274) and PD-L2 (PDCD1LG2), which are expressed on antigen-presenting cells (APCs) and various tissue cells, particularly in inflamed or tumor environments. The PD-1 pathway is critical for maintaining immune homeostasis, particularly in contexts where a controlled immune response is necessary, such as in infection and inflammation, and in preventing autoimmunity. PD-1 is often upregulated in chronic infections and cancer, where it contributes to immune exhaustion by inhibiting the function of T cells that would otherwise target infected or malignant cells. Given its role, PD-1 and its ligands have become significant targets for immunotherapy, especially in oncology, where blocking the PD-1/PD-L1 interaction can reinvigorate anti-tumor immunity.

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PDCD1 Antibody is a Rabbit Polyclonal antibody against PDCD1. This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

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