Programmed Cell Death Protein 1 (PDCD1) Antibody
299€ (50 µl)
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935106861
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name
Programmed Cell Death Protein 1 (PDCD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx402153
tested applications
ELISA, WB, IHC
Description
Programmed Cell Death Protein 1 (PDCD1) Antibody is a Recombinant Rabbit Monoclonal antibody for the detection of Human PDCD1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Programmed Cell Death Protein 1 (PDCD1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15116 |
| Alias | Protein PD-1,PD1,PD-1,CD279,SLEB2,hPD-1,hPD-l,hSLE1, |
| Background | Antibody anti-PDCD1 |
| Status | RUO |
Descripción
Programmed cell death 1 (PDCD1), commonly referred to as PD-1, is a transmembrane protein and immune checkpoint receptor expressed primarily on the surface of T cells, B cells, and some myeloid cells. PD-1 is encoded by the PDCD1 gene and plays a pivotal role in regulating immune responses by inhibiting T-cell activation, particularly in peripheral tissues during inflammation. It serves as a checkpoint receptor that, when engaged, dampens the immune response, promoting self-tolerance and preventing autoimmune reactions. PD-1 binds to its ligands, PD-L1 (CD274) and PD-L2 (PDCD1LG2), which are expressed on antigen-presenting cells (APCs) and various tissue cells, particularly in inflamed or tumor environments. The PD-1 pathway is critical for maintaining immune homeostasis, particularly in contexts where a controlled immune response is necessary, such as in infection and inflammation, and in preventing autoimmunity. PD-1 is often upregulated in chronic infections and cancer, where it contributes to immune exhaustion by inhibiting the function of T cells that would otherwise target infected or malignant cells. Given its role, PD-1 and its ligands have become significant targets for immunotherapy, especially in oncology, where blocking the PD-1/PD-L1 interaction can reinvigorate anti-tumor immunity.
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